Nurse Resignation Letter – 2 Weeks Notice (5 Samples)

Updated on: September 14, 2025

Navigating the decision to resign from a nursing position can be challenging.

Whether you’re moving on for personal reasons, career advancement, or other factors, a well-crafted resignation letter is essential to leave on good terms.

The following is a collection of five nurse resignation letter samples. Each is tailored for specific scenarios and provides the perfect templates to guide you in formally announcing your departure while maintaining professionalism and gratitude.

5 Nurse Resignation Letter Samples (2 Weeks’ Notice)

Sample 1: Standard Resignation Letter

John Doe
123 Maple Street
Columbus, OH 43215
[email protected]
(555) 123-4567
September 14, 2025

Jane Smith
Director of Nursing
Columbus General Hospital
456 Elm Street
Columbus, OH 43215

Dear Ms. Smith,

I am writing to formally resign from my position as a nurse at Columbus General Hospital, effective two weeks from today, September 28, 2025. This decision was not easy, but after careful consideration, I believe it is time for me to pursue new opportunities.

I am grateful for the support I received during my time at Columbus General and the valuable experiences that helped me grow professionally and personally. I will do my best to ensure a smooth transition over the next two weeks.

Thank you for everything.

Sincerely,
John Doe


Sample 2: Resignation Due to Personal Reasons

Emily White
789 Oak Avenue
Columbus, OH 43215
[email protected]
(555) 987-6543

September 14, 2025

Tom Johnson
Clinical Manager
Columbus Community Clinic
321 Pine Street
Columbus, OH 43215

Dear Mr. Johnson,

I am writing to inform you of my resignation from my nursing position at Columbus Community Clinic, effective two weeks from today, September 28, 2025. Due to personal reasons, I find it necessary to take this step.

I appreciate the opportunities I have had to work alongside such a talented team and will cherish the relationships I have built here. I am committed to ensuring a seamless transition during my remaining time.

Thank you for your understanding.

Best regards,
Emily White


Sample 3: Resignation for Career Advancement

Michael Brown
456 Birch Road
Columbus, OH 43215
[email protected]
(555) 654-3210
September 14, 2025

Sarah Davis
Head Nurse
Lincoln Medical Center
987 Cedar Street
Columbus, OH 43215

Dear Sarah,

I am writing to formally resign from my position as a nurse at Lincoln Medical Center, effective September 28, 2025. I have accepted a new role that will allow me to further develop my nursing career.

I am extremely grateful for the mentorship and guidance I received while working with you and my colleagues. It has truly been an invaluable experience.

I will ensure all my duties are fulfilled during my remaining time and will assist in the transition process as needed.

Thank you once again.

Sincerely,
Michael Brown


Sample 4: Resignation Due to Relocation

Laura Green
234 Willow Lane
Columbus, OH 43215
[email protected]
(555) 789-0123

September 14, 2025

David Miller
Administrator
Riverbend Health
654 Spruce Street
Columbus, OH 43215

Dear David,

I am writing to announce my resignation from Riverbend Health, effective two weeks from today, September 28, 2025. Due to my moving to a different city, I must leave my position.

I am thankful for the experiences I have gained and the wonderful team I have had the pleasure to work with. I am committed to completing all necessary tasks before my departure.

Thank you for understanding, and I hope to remain in touch.

Warm regards,
Laura Green


Sample 5: Resignation for Health Reasons

Chris Johnson
567 Aspen Way
Columbus, OH 43215
[email protected]
(555) 321-4567
September 14, 2025

Karen Taylor
Nursing Supervisor
Columbus Healthcare
321 River Road
Columbus, OH 43215

Dear Karen,

I am writing this letter to formally resign from my nursing position at Columbus Healthcare, effective September 28, 2025, due to health reasons that require my immediate attention.

This was a difficult decision to make, as I have greatly valued my time here and the relationships I have fostered. I appreciate all the support and understanding from the team during this challenging time.

I will do everything in my power to assist with the transition in my remaining time.

Thank you for your understanding.

Sincerely,

Chris Johnson


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Frequently Asked Questions

1. What is a nurse resignation letter?

A nurse resignation letter is a formal written notice from a nurse to their employer, indicating the intention to leave their job. It typically includes the effective date of resignation and may state the reasons for leaving.

2. Why is it important to give two weeks’ notice?

Giving two weeks’ notice is a professional courtesy that allows the employer time to find a replacement and ensure a smooth transition. It’s considered standard practice in many industries, including healthcare.

3. Can I customize the resignation letter samples provided?

Yes, you can customize the samples to fit your specific situation, tone, and the relationship you have with your employer. Adjust the content to reflect your personal circumstances and feelings.

4. What should I include in my resignation letter?

Your resignation letter should include:

  • Your intention to resign
  • The effective date of your resignation
  • A brief reason for your departure (optional)
  • Expressions of gratitude for the opportunities you received
  • A commitment to assist with the transition

5. Are there different types of resignation letters?

Yes, resignation letters can vary depending on the reason for leaving. The samples provided include letters for standard resignations, personal reasons, career advancement, relocation, and health issues.

6. Is it necessary to state the reason for leaving in the letter?

No, it’s not mandatory to state your reason for leaving. You can keep it brief and general if you prefer, focusing primarily on your intention to resign.

7. How do I address the resignation letter?

Address the resignation letter to your immediate supervisor or the appropriate person in the organization, such as the director of nursing or human resources manager, depending on the workplace structure.

8. Should I mention my next job in my resignation letter?

It is not necessary to mention your next job. If you choose to do so, keep it brief and professional. Your focus should be on your current resignation and expressing gratitude for your time at the organization.

9. What if I have a negative experience at my job?

If you had a negative experience, it’s best to keep your resignation letter positive and professional. Focus on your gratitude for any positive aspects rather than detailing any grievances.

10. How should I deliver my resignation letter?

It is best to deliver your resignation letter in person to your supervisor and then follow up with a formal email or printed copy. This approach shows professionalism and respect.

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